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Nialamide
Systematic (IUPAC) name
N-benzyl-3-(N'-pyridin-4-ylcarbonylhydrazino) -propanamide
Identifiers
CAS number	51-12-7
ATC code	N06AF02
PubChem	4472
Chemical data
Formula	C16H18N4O2
Mol. mass	298.34 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	Renal[1]
Therapeutic considerations
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral, intramuscular,[2] intravenous[3]

Nialamide was one of the first MAOI (monoamine oxidase inhibitor) antidepressants. It is chemically related to iproniazide, another MAOI derived from isonicotinic acid.

Contents 1 Uses 1.1 Approved 1.2 Unapproved/Off-Label/Investigational 2 Side effects 3 Tradenames 4 References and End Notes

Nialamide is effective for depression characterized by anergic symptoms,^[4] endogenous depression,^[5] and reactive depression.^[6]

Nialamide is sometimes used in the treatment of trigeminal neuralgia. It has also been studied for alcoholism,^[7] dermatomally distributed vitiligo,^[8] irregular menstrual cycle,^[9], angina,^[10] cerebrovascular disorders,^[11] and the prevention of streptomycin-induced deafness.^[12]

Side effects of nialamide include insomnia, vertigo, hyperhidrosis, weight gain, vomiting, tachycardia, constipation, dry mouth, upset stomach, orthostatic hypotension and decreased systolic pressure.

Nialamide is sold under Psicodisten®, Niaquitil®, Nialamid®, Niamidal®, Niamide®, Novazid®, Nuredal®, Niamid® (Italy, Belgium, Netherlands, England, United States)^[13], Niazin®, Nyazin®, Surgex® (Italy)^[14], Mygal®, Delmoneurina®, Isalizina® (Italy)^[15], Espril® (Italy)^[16], and Nyezin®.^[17]

1. ↑  NIALAMIDE. BIAM Database (2001). Retrieved on August 27, 2005.
2. ↑  Benady DR, Clein LJ, Pare CM (1965). "Intramuscular nialamide in intractable depression". Diseases of the Nervous System 26 (12): 792-4.  [No abstract] PMID 5321917 List of Print Collections
3. ↑  Oules J, Cabazon (1964). "[TREATMENT OF DEPRESSIVE STATES WITH INTRAVENOUS NIAMIDE.]". Toulouse Medical 65 (1): 1298-302. PMID 14272189.  [Article in French] New York Academy of Medicine Library holding
4. ↑  Vaisberg M, McGahee CL, Radinger N, Saunders JC (1959). "Nialamide for the treatment of anergy and depression". Diseases of the Nervous System 20 (Supplemental): 22-5. PMID 13840714.  List of Library Holdings
5. ↑  Van Reeth PC, Bloch C (1960). "[Treatment of endogenous depressions by a new inhibitor of monoamine oxidase: nialamide.]". Acta Neurologica Belgica 60 (1): 320-7.  [Article in French] PMID 13841128 Harvard University Library Holding
6. ↑  Cormary M (1966). "[Use of parenteral nialamide in the treatment of reactive or neurotic depressive states]". Lyon Medical 215 (15): 1051-62.  [Article in French] PMID 5930244 List of Library Holdings
7. ↑  Bobrov AE, Shurygin AN, Krasil'nikov SB (1991). "[Effectiveness of combined use of monoamine oxidase inhibitors and psychotherapy in the treatment of chronic alcoholism]". Zhurnal Nevropatologii i Psikhiatrii Imeni SS Korsakova. 91 (2): 79-83.  [Article in Russian] PMID 1647635 List of Library Holdings
8. ↑  Koga M (1977). "Vitiligo: a new classification and therapy". British Journal of Dermatology 97 (3): 255-61. PMID 921895.  List of Library Holdings
9. ↑  Gautray JP, Jolivet A (1976). "[Neuroendocrine investigation and therapy of the menstrual cycle disorders (author's transl)(proceedings)]". Annales d'Endocrinologie 37 (4): 293-4. PMID 1022189.  List of Library Holdings
10. ↑  Barats SS, Oranskii IE, Kartashova DI, Gorovater EN (1976). "[Comparative clinico-physiological study of the effect of several MAO inhibitors in stenocardia]". Kardiologiia 16 (3): 138-40.  [Article in Russian] No absract. PMID 1021625 List of Library Holdings
11. ↑  Mirzoian RS (1975). "[Prevention of cerebrovascular disorders with adrenergic substances]". Biulleten' Eksperimental'noi Biologii i Meditsiny 80 (11): 50-3.  [Article in Russian] PMID 1218262 List of Library Holdings
12. ↑  Semczuk B, Klonowski S, Golabek W (1974). "The protective effect of niamid on hearing in patients treated with large doses of streptomycin". Annales Universitatis Mariae Curie-Sklodowska Sectio D: Medicina 29 (1): 193-7.  No abstract. PMID 4467804 List of Library Holdings
13. ↑  Anonymous (2001). NIALAMIDE. Antidepresseurs. BIAM. Retrieved on 27 August 2005.
14. ↑  see BIAM, 2001.
15. ↑  see BIAM, 2001.
16. ↑  see BIAM, 2001.
17. ↑  SID 35970 -- PubChem Substance Summary - Depositor-Supplied Synonyms: All. Retrieved on 25 September 2005. National Center for Biotechnology Information.

v • d • e Antidepressants (ATC N06A)
Monoamine oxidase inhibitors (MAOI)	Harmaline, Iproniazid, Isocarboxazid, Nialamide, Pargyline, Phenelzine, Selegiline, Toloxatone, Tranylcypromine RIMAs: Brofaromine, Moclobemide
Dopamine reuptake inhibitor (DARI)	Amineptine, Phenmetrazine, Vanoxerine
Norepinephrine-dopamine reuptake inhibitors (NDRI)	Bupropion
Norepinephrine reuptake inhibitor (NRI) or (NARI)	Atomoxetine, Maprotiline, Reboxetine, Viloxazine
Serotonin-norepinephrine reuptake inhibitor (SNRI)	Duloxetine, Milnacipran, Nefazodone , Venlafaxine
Selective serotonin reuptake inhibitor (SSRI)	Alaproclate, Citalopram, Escitalopram, Etoperidone, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Zimelidine
Selective serotonin reuptake enhancer (SSRE)	Tianeptine
Noradrenergic and specific serotonergic antidepressant (NaSSA)	Mirtazapine
Tricyclic antidepressants (TCA)	Amitriptyline, Amoxapine, Butriptyline, Clomipramine, Desipramine, Dibenzepin, Dothiepin, Doxepin, Imipramine, Iprindole, Lofepramine, Melitracen, Nortriptyline, Opipramol, Protriptyline, Trimipramine
Tetracyclic antidepressants	Maprotiline, Mianserin, Nefazodone, Trazodone