Osteocalcin

From Wikipedia, the free encyclopedia

bone gamma-carboxyglutamate (gla) protein (osteocalcin)
Identifiers
Symbol BGLAP
HUGO 1043
Entrez 632
OMIM 112260
RefSeq NM_199173
UniProt P02818
Other data
Locus Chr. 1 q25-q31

Osteocalcin is a noncollagenous protein found in bone and dentin. It is secreted by osteoblasts and thought to play a role in mineralization and calcium ion homeostasis. It has been stipulated that osteocalcin may also function as a negative regulator of bone formation, although its exact role is unknown.

As osteocalcin is manufactured by osteoblasts, it is often used as a biochemical marker, or biomarker, for the bone formation process. It has been routinely observed that higher serum-osteocalcin levels are relatively well correlated with increases in bone mineral density (BMD) during treatment with anabolic bone formation drugs for osteoporosis, such as Forteo. In many studies, Osteocalcin is used as a preliminary biomarker on the effectiveness of a given drug on bone formation.

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Carrier protein: calcium-binding proteins

Annexin (A1, A2, A5) - Vitamin D-dependent calcium-binding protein/Calbindin - Calexcitin - Calsequestrin - Osteocalcin - Osteonectin - S-100 - Synaptotagmin - Troponin C

Intracellular calcium-sensing proteins: Calmodulin - Calnexin - Calreticulin - Gelsolin - neuronal (Hippocalcin, Neurocalcin, Recoverin)

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