Osteonectin

From Wikipedia, the free encyclopedia

secreted protein, acidic and rich in cysteine (osteonectin)
Identifiers
Symbol	SPARC ON
HUGO	11219
Entrez	6678
OMIM	182120
RefSeq	NM_003118
UniProt	P09486
Other data
Locus	Chr. 5 q31-q33

Osteonectin is a glycoprotein in the bone that binds calcium. It is secreted by osteoblasts during bone formation, initiating mineralization and promoting mineral crystal formation. Osteonectin also shows affinity for collagen in addition to bone mineral calcium. Some current research shows a correlation between osteonectin over expression and ampullary cancers and chronic pancreatitis.

MeSH Osteonectin

This biochemistry article is a stub. You can help Wikipedia by expanding it.

v • d • e

Carrier protein: calcium-binding proteins

Annexin (A1, A2, A5) - Vitamin D-dependent calcium-binding protein/Calbindin - Calexcitin - Calsequestrin - Osteocalcin - Osteonectin - S-100 - Synaptotagmin - Troponin C

Intracellular calcium-sensing proteins: Calmodulin - Calnexin - Calreticulin - Gelsolin - neuronal (Hippocalcin, Neurocalcin, Recoverin)

Retrieved from "http://en.wikipedia.org../../../o/s/t/Osteonectin.html"

Categories: Protein pages needing a picture | Genes on chromosome 5 | Biochemistry stubs | Glycoproteins | Carbohydrates

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