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Class III PI 3-kinase
From Wikipedia, the free encyclopedia
Class III PI 3-kinase is a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation.
There is only one known class III PI 3-kinase , Vps34, it is also the only PI 3-kinase expressed in all eukaryotic cells. In humans it is encoded by the PIK3C3 gene. In human cells Vps34 associates with a regulatory subunit, p150.
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Vps34 is more accurately described as a phosphatylinositol 3-kinase. In vivo Vps34 can only phosphorylate Phosphatidylinositol to form phosphatidylinositol (3)-phosphate (PtdIns(3)P).
Vps34 was first identified in a Saccharomyces cerevisiae (budding yeast) screen for proteins involved vesicle-mediated vacuolar protein sorting (hence Vps). A number of proteins containing a phosphoinositide binding domain specific for PtdIns(3)P have been identified which function in cellular protein trafficking.
FYVE domain
- Stein RC( 2001) Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment Endocr Relat Cancer 8:237-248 [1]
- Foster FM, Traer CJ, Abraham SM, and Fry MJ (2003) The phosphoinositide (PI) 3-kinase family J Cell Sci 116:3037-3040.[2]
- Vanhaesebroeck B, Waterfield MD.(1999) Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res. 253(1):239-54.[3]
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