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Pacinian corpuscle
Pacinian corpuscle, with its system of capsules and central cavity. a. Arterial twig, ending in capillaries, which form loops in some of the intercapsular spaces, and one penetrates to the central capsule. b. The fibrous tissue of the stalk. n. Nerve tube advancing to the central capsule, there losing its white matter, and stretching along the axis to the opposite end, where it ends by a tuberculated enlargement.
Pacinian capsule labeled at bottom.
Latin	corpusculum lamellosum
Gray's	subject #233 1060
MeSH	Pacinian+Corpuscles
Dorlands/Elsevier	c_56/12261365

Pacinian corpuscles are one of the four major types of mechanoreceptor. They are nerve endings in the skin, responsible for sensitivity to deep pressure touch and high frequency vibration.

Contents 1 Location 2 Structure 3 Function 4 Nomenclature 5 Additional images 6 References 7 See also 8 External links

These corpuscles are found in mesenteries, especially the pancreas, and are often found near joints.

Like Ruffini endings, they are found in deep subcutaneous tissue, and are considered rapidly adapting receptors, which means they will not fire action potentials throughout the duration of a stimulus but, rather, will fire briefly at its beginning and end (Kandel et al., 2000).

Similar in physiology to the Meissner's corpuscle, Pacinian corpuscles are larger and fewer in number than both Merkel cells and Meissner's corpuscles (Kandel et al., 2000).

The Pacinian corpuscle is oval shaped and approximately 1 mm in length. The entire corpuscle is wrapped by a layer of connective tissue. It has 20 to 60 concentric lamellae composed of fibrous connective tissue and fibroblasts, separated by gelatinous material. The lamellae are very thin, flat, modified Schwann cells. In the center of the corpuscle is the inner bulb, a fluid-filled cavity with a single afferent unmyelinated nerve ending.

Pacinian corpuscles detect gross pressure changes and vibrations. Any deformation in the corpuscle causes action potentials to be generated, by opening pressure-sensitive sodium ion channels in the axon membrane. This allows sodium ions to influx in, creating a receptor potential.

These corpuscles are especially susceptible to vibrations, which they can sense even centimeters away (Kandel et al., 2000). Pacinian corpuscles cause action potentials when the skin is rapidly indented but not when the pressure is steady, due to the layers of connective tissue that cover the nerve ending (Kandel et al., 2000). It is thought that they respond to high velocity changes in joint position.

Pacinian corpuscles have a large receptive field on the skin's surface with an especially sensitive center (Kandel et al., 2000). They only sense stimuli that occur within this field.

The Pacinian corpuscle was named after its discoverer, Italian anatomist Filippo Pacini.

The term "Golgi-Mazzoni corpuscle" (distinct from the Golgi organ) is used to describe a similar structure found only in the fingertips. (c_56/12261088 at Dorland's Medical Dictionary, synd/2423 at Who Named It)

diagrammatic sectional view of the skin (magnified).

Schema (German)

light micrograph showing three corpuscles in the center of the field

• Kandel ER, Schwartz JH, Jessell TM. Principles of Neural Science, 4th ed., p.433. McGraw-Hill, New York (2000). ISBN 0-8385-7701-6

• List of human anatomical parts named after people.

• Virginia Commonwealth University
• Anatomy Atlases - Microscopic Anatomy, plate 06.124
• lamellated+corpuscles at eMedicine Dictionary

v • d • e Nervous system, receptors: somatosensory system
Medial lemniscus	Touch/mechanoreceptors: Pacinian corpuscles • Meissner's corpuscles • Merkel's discs • Ruffini endings • Free nerve endings • Hair cells • Baroreceptor Proprioception: Golgi organ • Muscle spindle (Intrafusal muscle fiber • Nuclear chain fiber • Nuclear bag fiber)
Spinothalamic tract	Pain: Nociceptors Temperature: Thermoreceptors