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The Pfam database contains information about protein domains and families. Pfam-A is the manually curated portion of the database that contains over 8,000 entries. For each entry a protein sequence alignment and a Hidden Markov Model is stored. These Hidden Markov Models can be used to search sequence databases with the HMMer package written by Sean Eddy. Because the entries in Pfam-A do not cover all known proteins an automatically generated supplement is provided called Pfam-B. Pfam-B is derived from the PRODOM database.

The database iPfam builds on the domain description of Pfam. It investigates if different proteins described together in the protein structure database PDB are close enough to potentially interact.

• TrEMBL Database performing an automated protein sequence annotation
• InterPro Integration of protein domain and protein family databases

• Finn RD, Mistry J, Schuster-Bockler B, Griffiths-Jones S, Hollich V, Lassmann T, Moxon S, Marshall M, Khanna A, Durbin R, Eddy SR, Sonnhammer EL, Bateman A (2006). "Pfam: clans, web tools and services". Nucleic Acids Res. 34: D247-D251. PMID 16381856. 

• Finn RD, Marshall M, Bateman A (2005). "iPfam: visualization of protein-protein interactions in PDB at domain and amino acid resolutions". Bioinformatics 21: 410-412. PMID 15353450. 

• Bateman A, Coin L, Durbin R, Finn RD, Hollich V, Griffiths-Jones S, Khanna A, Marshall M, Moxon S, Sonnhammer EL, Studholme DJ, Yeats C, Eddy SR (2004). "The Pfam protein families database". Nucleic Acids Res. 32(Database issue): D138-D141. PMID 14681378. 

• Pfam - Protein family database at Sanger Institute
• iPfam - Interactions of Pfam domains in PDB

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