Phosphatidylcholine

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A typical molecule of phosphatidylcholine; here containing palmitoyl and oleoyl acyl chains.
A typical molecule of phosphatidylcholine; here containing palmitoyl and oleoyl acyl chains.

Phosphatidylcholine or Polyenylphosphatidylcholine[1] is a phospholipid that is the major component of a phosphatide fraction, which may be isolated from either egg yolk (in Greek lekithos - λεκιθος) or soy beans from which it is mechanically or chemically extracted using hexane.

It is such a major component of lecithin, that, in some contexts, the terms are sometime used as synonyms. However, lecithin extract consists of a mixture of phosphatidylcholine and other compounds. It is also used along with Sodium taurocholate for simulating fed- and fasted-state biorelevant media in dissolution studies of highly-lipophilic drugs. Phosphatidylcholine is a major constituent of cell membranes.

Phospholipase D catalyzes the hydrolysis of phosphatidylcholine to form phosphatidic acid (PA), releasing the soluble choline headgroup into the cytosol.

Some medical researchers are experimenting with using Phosphatidylcholine in a type of injection that will break down fat cells; to be used as an alternative to liposuction (see link below).

Membrane lipids

Choline metabolism

Phosphatidate

Choline

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v • d • e
Lipids: phospholipids
Glycerol backbone (Glycerophospholipids/Phosphoglycerides) Phosphatidylethanolamine/Cephalin - Phosphatidylcholine - Dipalmitoylphosphatidylcholine - Cardiolipin - Phosphatidylserine - Ether lipids (Plasmalogen, Platelet-activating factor) - Phosphatidylinositol - Glycophosphatidylinositol - PIP1 - PIP2 (3,4, 3,5, 4,5) - PIP3
Sphingosine backbone Sphingomyelin
Other Phosphatidate
v • d • e
Cell signaling: lipid signaling
Phospholipase - PIP2 - DAG - IP3 - IP3 receptor
Retrieved from "http://en.wikipedia.org/wiki/Phosphatidylcholine"
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