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Phosphotransferase
From Wikipedia, the free encyclopedia
Phosphotransferases are a category of enzymes (EC 2.7 2.7) which catalyze phosphorylation reactions. The general form is:
A—P + B ⇔ B—P + A
Where P is a phosphate group and A and B are the donating and accepting molecules, respectively.
This system is used by, for example, bacterias, to transport sugar (Glucose) into the cell. It is rather complex, and the first step of this reaction adds a Phosphor to the Glucose (via Phosphotransferase), producing Glucose-6-Phosphate. Due to the negative current of the Phosphate, this Glu6P can no longer freely leave the cell, and it is additionally the first reaction of Glycolysis (which will degrade the sugar to Pyruvate)
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Active site - Binding site - Catalytically perfect enzyme - Coenzyme - Cofactor - EC number - Enzyme catalysis - Enzyme kinetics - Enzyme inhibitor - Lineweaver-Burk plot - Michaelis-Menten kinetics
EC1 Oxidoreductases,O+R+D/list (alcohol oxidoreductases, CH-CH oxidoreductases, peroxidase, oxygenase) - EC2 Transferases/list (methyltransferase, acyltransferase, glycosyltransferase, transaminase, phosphotransferase, polymerase, kinase) - EC3 Hydrolases/list (esterase, DNA glycosylases, glycosidase, protease, acid anhydride hydrolases) - EC4 Lyases/list (carboxy-lyases, aldolase, dehydratase, synthase, adenylate cyclase, guanylate cyclase) - EC5 Isomerases/list (mutase, topoisomerase) - EC6 Ligases/list (DNA ligase, aminoacyl tRNA synthetase)