Platelet factor 4

From Wikipedia, the free encyclopedia

platelet factor 4, chemokine (C-X-C motif) ligand 4
Identifiers
Symbol	PF4 CXCL4, SCYB4
HUGO	8861
Entrez	5196
OMIM	173460
RefSeq	NM_002619
UniProt	P02776
PDB	1RHP
Other data
Locus	Chr. 4 q12-q21

Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. Due to these roles, it is predicted to play a role in wound repair and inflammation.^[1] It is usually found in a complex with proteoglycan. PF4 is chemotactic for neutrophils, fibroblasts and monocytes, and interacts with a splice varient of the chemokine receptor CXCR3, known as CXCR3B.^[2] The gene for human PF4 is located on human chromosome 4.^[3]

^ Eisman R, Surrey S, Ramachandran B, Schwartz E, Poncz M (1990). "Structural and functional comparison of the genes for human platelet factor 4 and PF4alt". Blood 76 (2): 336-44. PMID 1695112.
^ Lasagni L, Francalanci M, Annunziato F, Lazzeri E, Giannini S, Cosmi L, Sagrinati C, Mazzinghi B, Orlando C, Maggi E, Marra F, Romagnani S, Serio M, Romagnani P (2003). "An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4". J Exp Med 197 (11): 1537-49. PMID 12782716.
^ O'Donovan N, Galvin M, Morgan J (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet Cell Genet 84 (1-2): 39-42. PMID 10343098.