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Pancreatic polypeptide
From Wikipedia, the free encyclopedia
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pancreatic polypeptide
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| Identifiers | |
| Symbol | PPY |
| HUGO | 9327 |
| Entrez | 5539 |
| OMIM | 167780 |
| RefSeq | NM_002722 |
| UniProt | P01298 |
| Other data | |
| Locus | Chr. 17 p11.1-qter |
Pancreatic polypeptide is an polypeptide secreted by PP cells in the endocrine pancreas predominantly in the head of the pancreas. It consists of 36 amino acids and has molecular weight about 4200 Da.
Pancreatic polypeptide is a cholecystokinin antagonist. It suppresses the pancreatic secretion and stimulates gastric secretion.
Its secretions in humans is increased after a protein meal, fasting, exercise, and acute hypoglycemia and is decreased by somatostatin and intravenous glucose. The function of PP is unknown, but effects on hepatic glycogen levels and gastrointestinal secretions have been suggested.
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Islets of Langerhans: alpha cell (glucagon) • beta cell (insulin) • delta cell (somatostatin) • PP cell (pancreatic polypeptide) • epsilon cell (ghrelin)
Angiotensin - Bombesin - Bradykinin - Calcitonin - Calcitonin gene-related peptide - Carnosine - Cholecystokinin - Delta sleep-inducing peptide - FMRFamide - Galanin - Gastric inhibitory polypeptide - Gastrin releasing peptide - Gastrin - Motilin - Neuromedin B - Neuropeptide Y - Neurophysins - Neurotensin - Opioid peptide - Pancreatic polypeptide - Pituitary adenylate cyclase activating peptide - Secretin - Tachykinins - Vasoactive intestinal peptide - Vasopressin
Hypothalamic: Somatostatin - CRH - GnRH - GHRH - Orexins - TRH - POMC (ACTH, MSH, Lipotropin)