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Protein family
From Wikipedia, the free encyclopedia
A protein family is a group of evolutionarily related proteins.
As the total number of sequenced proteins increases and interest expands in proteome analysis, there is an ongoing effort to organize proteins into families and to describe their component domains and motifs. Reliable identification of protein families is key to phylogenetic analysis, functional annotation and the exploration of diversity of protein function in a given phylogenetic branch.
The algorithmic means for establishing protein families on large scale are based on a notion of similarity. Most of the time the only similarity we have access to is sequence similarity.
Many times these families are the result of gene duplication events. One of the more popular protein families is the Globin protein family.
- Pfam - Protein families database of alignments and HMMs
- PIRSF - SuperFamily Classification System
- PASS2 - Protein Alignment as Structural Superfamilies v2 - PASS2@NCBS
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