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Protein kinase R
From Wikipedia, the free encyclopedia
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eukaryotic translation initiation factor 2-alpha kinase 2
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| Identifiers | |
| Symbol | EIF2AK2 PRKR, PKR, EIF2AK1 |
| HUGO | 9437 |
| Entrez | 5610 |
| OMIM | 176871 |
| RefSeq | NM_002759 |
| UniProt | P19525 |
| Other data | |
| Locus | Chr. 2 p22-p21 |
Protein kinase R (PKR) is activated by double-stranded RNA (dsRNA) and plays a major role in the cellular response to viral infection. PKR can also be activated by the protein PACT or by heparin. PKR contains an N-terminal dsRNA binding domain (dsRBD) and a C-terminal kinase domain. The dsRBD consists of two tandem copies of a conserved double stranded RNA binding motif, dsRBM1 and dsRBM2. PKR is induced by interferon in a latent state. Binding to dsRNA is believed to activate PKR by inducing dimerization and subsequent autophosphorylation reactions.
Active site - Binding site - Catalytically perfect enzyme - Coenzyme - Cofactor - EC number - Enzyme catalysis - Enzyme kinetics - Enzyme inhibitor - Lineweaver-Burk plot - Michaelis-Menten kinetics
EC1 Oxidoreductases,O+R+D/list (alcohol oxidoreductases, CH-CH oxidoreductases, peroxidase, oxygenase) - EC2 Transferases/list (methyltransferase, acyltransferase, glycosyltransferase, transaminase, phosphotransferase, polymerase, kinase) - EC3 Hydrolases/list (esterase, DNA glycosylases, glycosidase, protease, acid anhydride hydrolases) - EC4 Lyases/list (carboxy-lyases, aldolase, dehydratase, synthase, adenylate cyclase, guanylate cyclase) - EC5 Isomerases/list (mutase, topoisomerase) - EC6 Ligases/list (DNA ligase, aminoacyl tRNA synthetase)
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