AAA proteins

From Wikipedia, the free encyclopedia

AAA or AAA+ is an abbreviation for ATPases Associated with various cellular Activities. It is a protein superfamily in which the member proteins share a highly conserved module of approximately 230 amino acid residues.

The characteristic of AAA proteins is the coupling of chemical energy by ATPase, provided by ATP hydrolysis, to mechanical force exerted on some macromolecular substrate. This usually requires a conformational change in the AAA protein in question.

Members of the AAA family are found in all organisms and they are essential for many cellular functions.


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