Protoporphyrinogen oxidase

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protoporphyrinogen oxidase
Identifiers
Symbol PPOX
Alt. Symbols VP
Entrez 5498
HUGO 9280
OMIM 600923
RefSeq NM_000309
UniProt P50336
Other data
EC number 1.3.3.4
Locus Chr. 1 q22

Protoporphyrinogen oxidase (EC 1.3.3.4) is an enzyme that is responsible for the seventh step in heme production. (Heme is the portion of hemoglobin that carries oxygen in the blood from the lungs to the rest of the body.)

Protoporphyrinogen oxidase removes hydrogen atoms from protoporphyrinogen IX (the product of the sixth step in the production of heme) to form protoporphyrin IX.

One additional enzyme must modify protoporphyrin IX before it becomes heme.


Heme synthesis—note that some reactions occur in the cytoplasm and some in the mitochondrion (yellow)
Heme synthesis—note that some reactions occur in the cytoplasm and some in the mitochondrion (yellow)


 This EC 1.3 enzyme-related article is a stub. You can help Wikipedia by expanding it.
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Protein: membrane proteins
Ankyrin - Arrestin - Calnexin - Connexin - Dystrophin - Ephrin - Heterotrimeric GTP-binding proteins - LDL-receptor-related protein associated protein - Membrane fusion protein (VAMP) - Membrane glycoproteins - Membrane transport proteins - Myelin basic protein - Neurofibromin 2 - Phospholipid transfer proteins - Pore forming toxins - Presenilin - Protoporphyrinogen oxidase - Pulmonary surfactant-associated protein B - Pulmonary surfactant-associated protein C - Spectrin - Tetraspanin - Transmembrane receptors - Utrophin - Vesicular transport proteins
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Oxidoreductases: CH-CH oxidoreductases (EC 1.3)
1.3.1. NAD/NADP acceptor Enoyl-acyl carrier protein reductase/Enoyl ACP reductase - 7-Dehydrocholesterol reductase - Biliverdin reductase - 2,4 Dienoyl-CoA reductase
1.3.3. Oxygen acceptor Dihydroorotate dehydrogenase - Coproporphyrinogen III oxidase - Protoporphyrinogen oxidase -
1.3.5. Quinone Succinate - coenzyme Q reductase
1.3.99. Other acceptors Fumarate reductase - Butyryl CoA dehydrogenase - Acyl CoA dehydrogenase - 5-alpha reductase - Glutaryl-CoA dehydrogenase - Isovaleryl coenzyme A dehydrogenase
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Porphyrin enzymes
Porphyrin biosynthesis Aminolevulinic acid synthase - Porphobilinogen synthase - Porphobilinogen deaminase - Uroporphyrinogen III synthase - Uroporphyrinogen III decarboxylase - Coproporphyrinogen III oxidase - Protoporphyrinogen oxidase - Ferrochelatase
Heme breakdown Heme oxygenase - Biliverdin reductase
Retrieved from "http://en.wikipedia.org/wiki/Protoporphyrinogen_oxidase"
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