RANTES

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The structure of human RANTES
chemokine (C-C motif) ligand 5
Identifiers
Symbol CCL5 D17S136E, SCYA5
HUGO 10632
Entrez 6352
OMIM 187011
RefSeq NM_002985
UniProt P13501
PDB 1PMI
Other data
Locus Chr. 17 q11.2-q12

Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8kDa protein classified as a chemotactic cytokine or chemokine. It has recently been renamed CCL5. RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e. IL-2 and IFN-γ) that are released by T cells, RANTES also induces the proliferation and activation of certain natural killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells.[1] It is also a HIV-suppressive factor released from CD8+ T cells. This chemokine has been localized to chromosome 17 in humans.[2]

  1. ^ Maghazachi et al, CC chemokines induce the generation of killer cells from CD56+ cells, Eur J Immunol. 1996, 26:315-9.
  2. ^ Donlon et al. Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12. Genomics 5: 548-553, 1990.


v • d • e
Cytokines: chemokines

CCL1 - CCL2 - CCL3 - CCL4 - CCL5 - CCL6 - CCL7 - CCL8 - CCL9 - CCL10 - CCL11 - CCL12 - CCL13 - CCL14 - CCL15 - CCL16 - CCL17 - CCL18 - CCL19 - CCL20 - CCL21 - CCL22 - CCL23 - CCL24 - CCL25 - CCL26 - CCL27 - CCL28

CXCL1 - CXCL2 - CXCL3 - CXCL4 - CXCL5 - CXCL6 - CXCL7 - CXCL8 - CXCL9 - CXCL10 - CXCL11 - CXCL12 - CXCL13 - CXCL14 - CXCL15 - CXCL16 - CXCL17

CX3CL1

XCL1 - XCL2

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