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In males, retrograde ejaculation occurs when the fluid to be ejaculated, which would normally exit via the urethra, is redirected towards the urinary bladder.

Normally the sphincter of the bladder contracts and the sperm goes to the urethra towards the area of least pressure. In retrograde ejaculation this sphincter does not function properly.

Causes may be in the autonomic nervous system or the operation of the prostate. Retrograde ejaculation is a common complication of trans-urethral resection of the prostate, a procedure in which diseased, or non-diseased (enlarged prostate) tissue is removed, slice by slice, through a resectoscope passed along the urethra.

Retrograde ejaculation is a common side effect of medications such as Tamsulosin that are used to relax the muscles of the urinary tract for various purposes. These medications may cause the bladder sphincter to relax as well and fail to contract fully.
But the medications that mostly cause it are antidepressant and antipsychotic medication, and the patients experiencing that tend to quit them^[1][2]

Retrograde ejaculation can also be a complication of diabetes especially in cases of diabetics with long term poor blood sugar control. This is due to neuropathy of the bladder sphincter.

Diagnosis is usually by way of a urinalysis performed on a urine specimen that is obtained shortly after ejaculation which will have an abnormal level of sperm within it.
Anejaculation often, especially in case of orgasmic anejaculation, can be confused with retrograde ejaculation, and they share some fundamental aspects of the etiology . Urinalysis is used also to distinguish between them.

Retrograde ejaculation may cause a couple to experience problems such as infertility, as most sperm do not get to the vagina and the rest of the female reproductive system. As a method to induce pregnancy, the retrograde ejaculator's urine is centrifuged and the isolated sperm is then injected into the woman.

Around 40% of sufferers from retrograde ejaculation have found that use of pseudoephedrine (brands names include Sudafed) noticeably improves the quantity of ejaculate.^{[citation needed]} The tricyclic antidepressant imipramine has also been used as an effective treatment for retrograde ejaculation. It must be noted that both medications have links to erectile dysfunction, pseudoephedrine being the frontline treatment for priapism. People with erectile dysfunction and retrograde ejaculation (not uncommon in those with diabetes) are strongly advised to seek medical advice about the best 'dual' treatment methods available to them, i.e. combining pseudoephedrine or an alternative with an erectile dysfunction treatments such as sildenafil.

In most cases those suffering from retrograde ejaculation are advised that a normal sex life is to be expected, however a significant number of those patients who do have it have reported reduced sensation during orgasm.

Taoists and some fields of alternative medicine actually recommend and teach retrograde ejaculation as a way of "conserving the body's energy". It is believed the sensation of sperm passing through the urethra causes intense physical sensations that can drain the body of "sexual energy". Others believe the energy is conserved physically within the sperm; however, there is no scientific basis for this, as the retrograde-ejaculated sperm are simply lost at the next urination. Many doctors do not recommend learning how to perform retrograde ejaculation, as once learnt, the habit may be hard to unlearn^{[citation needed]}.

One manner of achieving male retrograde ejaculation is by applying pressure to the perineum during orgasm^{[citation needed]}.

1. ^ [1] (Italian)
2. ^ [2] (Italian)

• http://www2.rz.hu-berlin.de/sexology/ECE1/retrograde.html
• Sexual Medicine Society of North America's website: SexHealthMatters.org