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Saxitoxin
From Wikipedia, the free encyclopedia
| Saxitoxin | |
| Chemical formula | C10H17N7O4 |
| Molecular mass | 299.29 g/mol |
| CAS number | 35523-89-8 |
| SMILES | N=C1N[C@@H](COC(N)=O) [C@H]3[C@]2(N=C(N)N3) N1CCC2(O)O |
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Saxitoxin (STX) is a neurotoxin found in marine dinoflagellates (algae). It is a selective sodium channel blocker. The United States military isolated saxitoxin and assigned it the chemical weapon designation TZ. It is unique among toxins in that it acts in a matter of minutes. The LCt50 of TZ is 5 mg·min/m³.
The medical importance of saxitoxin is in relation to red tide in shellfish and causes the paralytic shellfish poisoning (PSP) food poisoning. The blocking of the sodium channel produces a flaccid paralysis that leaves its victim calm and conscious through the progression of symptoms. Death is from respiratory failure.
It is listed in schedule 1 of the Chemical Weapons Convention. Though its early isolation and characterization were related to military efforts, saxitoxin has been more important to cellular research in describing the function of the sodium channel.
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