Serotonin receptor agonist
From Wikipedia, the free encyclopedia
A serotonin receptor agonist is a compound that activates serotonin receptors, mimicking the effect of the neurotransmitter serotonin. There are various serotonin receptors
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Buspirone, a 5-HT1A receptor agonist that is an anxiolytic medication.
Triptans are 5-HT1D receptor agonists that are used to abort migraine attacks.
Hallucinogens like LSD, mescaline and psilocybin act as 5-HT2A agonists, and action at this receptor is thought to be primarily responsible for their hallucinogenic effects (although the 5-HT1A and 5-HT2C receptors are also involved to a lesser extent)
Cisapride is a 5-HT4 receptor agonist that has been used to treat disorders of gastrointestinal motility.
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| Drugs for functional bowel disorders | antimuscarinics: Mebeverine - Dicycloverine - Propantheline
papaverine and derivatives: Papaverine - Drotaverine - Moxaverine acting on serotonin receptors: 5-HT3 antagonists (Alosetron, Cilansetron) - 5HT4 agonists (Mosapride, Tegaserod) other: Diisopromine - Isometheptene - Phloroglucinol - Proglumide - Tridihexethyl |
| Belladonna and derivatives (antimuscarinics) |
Atropine - Hyoscyamine - Butylscopolamine - Methylscopolamine |
| Propulsives | primarily dopamine antagonists (Metoclopramide/Bromopride, Domperidone, Alizapride) - serotonin agonists (Cisapride) - Clebopride |
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| Ergot alkaloids | Dihydroergotamine • Ergotamine • Methysergide • Lisuride |
| Corticosteroid derivatives | Flumedroxone |
| Selective serotonin (5-HT1) agonists | Triptans (Almotriptan, Eletriptan, Frovatriptan, Naratriptan, Rizatriptan, Sumatriptan, Zolmitriptan) |
| Other antimigraine preparations | Pizotifen • Clonidine • Iprazochrome • Dimetotiazine • Oxetorone |
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| Benzodiazepine | Adinazolam - Alprazolam - Bretazenil - Bromazepam - Camazepam - Chlordiazepoxide - Clobazam - Clorazepate - Clonazepam - Clotiazepam - Cloxazolam - Diazepam - Ethyl loflazepate - Etizolam - Fludiazepam - Halazepam - Imidazenil - Ketazolam - Lorazepam - Medazepam - Nordazepam - Oxazepam - Pinazepam - Prazepam - Tofisopam |
| Nonbenzodiazepine | Alpidem - Etifoxine - L-838,417 - Ocinaplon - Pagoclone - Panadiplon - Pipequaline - RWJ-51204 - Y-23684 |
| Diphenylmethane | Hydroxyzine - Captodiame |
| Carbamates | Emylcamate - Carisoprodol - Mebutamate - Meprobamate - Phenprobamate - Tybamate |
| β-Carbolines | Abecarnil - Gedocarnil - SL-651,498 |
| Dibenzo-bicyclo-octadiene | Benzoctamine |
| Azaspirodecanedione (serotonin agonist) |
Buspirone - Gepirone - Tandospirone |
| Other | Mephenoxalone |