Sources
Help build the largest human-edited directory on the web.
Submit a site - Become an editor
Wikipedia. Licensed under the GNU Free Documentation License.
Are you an expert in this subject? Join the discussion and share your knowledge at Wikipedia.org.
Structural genomics
From Wikipedia, the free encyclopedia
Structural genomics consists in the determination of the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography, NMR spectroscopy or computational approaches such as homology modelling.
As opposed to traditional structural biology, the determination of a protein structure through a structural genomics effort often (but not always) comes before anything is known regarding the protein function. This raises new challenges in structural bioinformatics, i.e. determining protein function from its 3D structure.
One of the important aspects of structural genomics is the emphasis on high throughput determination of protein structures. This is performed in dedicated centers of structural genomics.
While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large scale cloning, expression and purification. One main advantage of this approach is economy of scale. On the other hand, the scientific value of some resultant structures is at times questioned. An interesting Science article from January 2006 analyzes the structural genomics field.
- Structural Genomics Consortium
- Protein Structure Initiative
- Northeast Structural Genomics Consortium
- The Midwest Center for Structural Genomics
- Berkeley Structural Genomics Center
- Center for Eukaryotic Structural Genomics
- Yeast Structural Genomics (Genomique Structurale de la levure)
- RIKEN Structural Genomics/Proteomics Initiative
- Structural Genomics of Pathogenic Protozoa
- The Joint Center for Structural Genomics
- Mycobacterium tuberculosis Structural Genomics Consortium
- New York Structural Genomics Research Consortium (NYSGRC)
- NJCST Initiative in Structural Genomics and Bioinformatics
- Structural Genomics at Brookhaven Natl. Labs
- Structure to Function Pilot Project: CARB
- The Southeast Collaboratory for Structural Genomics
- Toronto Structural Proteomics Consortium
- Protein Structure Factory
- Oxford Protein Production Facility
- Structural Proteomics in Europe SPINE
| Genomics topics |
| Genome project | Paleopolyploidy | Glycomics | Human Genome Project | Proteomics |
| Chemogenomics | Structural genomics | Pharmacogenetics | Pharmacogenomics | Toxicogenomics |
| Bioinformatics | Cheminformatics | Systems biology |
 |
This genetics article is a stub. You can help Wikipedia by expanding it. |