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Sulbutiamine
From Wikipedia, the free encyclopedia
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Sulbutiamine
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| Systematic (IUPAC) name | |
| [4-[(4-amino-2-methyl-pyrimidin-5-yl)methyl-formyl- amino]-3-[2-[(4-amino-2-methyl-pyrimidin-5-yl)methyl- formyl-amino]-5-(2-methylpropanoyloxy)pent-2-en-3- yl]disulfanyl-pent-3-enyl] 2-methylpropanoate |
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| Identifiers | |
| CAS number | |
| ATC code | A11 |
| PubChem | |
| Chemical data | |
| Formula | C32H46N8O6S2 |
| Mol. mass | 702.89 g/mol |
| SMILES | search in , |
| Synonyms | Arcalion, bisibuthiamine, youvitan |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | 5 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Oral |
Sulbutiamine (brand name: Arcalion®) is a precursor to thiamine (i.e., vitamin B1). It is indicated for the treatment of asthenia.[1] Furthermore, the ability of sulbutiamine to reduce fatigue is considered desirable by athletes, and a patented combination of it and caffeine called Spike® is available for over-the-counter sale as a nutritional supplement. Additionally, the demonstrated ability of sulbutiamine to improve memory in rats[2] and patients of schizophrenia[2] suggests that it is a nootropic.
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Sulbutiamine reduces fatigue, memory difficulties, intellectual tiredness and may speed convalescence.[3]
Sulbutiamine is supplied in 200 mg tablets. The proper therapeutic dosage has been reported to be 12.5 mg/kg,[2] which corresponds to 850 mg for a 68 kg (150 lb) person. However, it should be noted that dosage recommendations vary; the manufacturer of Arcalion, for example, recommends no more than 600 mg per day.
- ^ Shah SN; Sulbutiamine Study Group (2003). "Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia.". J Assoc Physicians India 51: 891–5. PMID 14710977.
- ^ a b c Bizot JC, Herpin A, Pothion S, Pirot S, Trovero F, Ollat H (2005). "Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task.". Prog Neuropsychopharmacol Biol Psychiatry 29 (6): 928–35. PMID 15951087.
- ^ http://www.serdiapharma.com/about/arcalion.asp