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Susan Tyrrell (born March 18, 1945 in San Francisco, California) is an Academy Award-nominated American actress of Irish descent.

Her father was a top agent at one time with the William Morris firm (talent agency). She built up her resumé in summer stock and regional plays, usually cast in standard ingénue roles, although her theatre roles would grow larger once she came to New York City.

After her film debut in Shoot Out (1971), her performance as Oma in Fat City brought her a 1972 Academy Award nomination for Best Supporting Actress.

Susan Tyrrell played Solly, a tough, foul-mouthed lesbian, in both 1980s cult-films Angel (1984 film) and Avenging Angel. In the first film she sparred with co-star Dick Shawn over a game of cribbage, and in the sequel, Solly acted as den-mother to a group of tranvestite prostitutes and raised an abandoned baby.

In early 2000, she suffered the loss of both legs as a result of blood clots due to the rare blood disease essential thrombocythemia. She has continued to work, playing Ella the Fortune Teller in Masked and Anonymous (2003) and the High Priestess in The Devil's Due at Midnight (2004).

She is sometimes credited as Susan Tyrell in her early films. At her request, her narration for Ralph Bakshi's Wizards was uncredited. However, the film brought her so much work, she later told Bakshi she regretted not taking a credit.

She is also a composer, credited with the song Witch's Egg in Forbidden Zone, the 1980 low-budget indie film by musical group Oingo Boingo (in which she also stars).

• The Devil's Due at Midnight (2004)
• Masked and Anonymous (2003)
• Buddy Boy (1999)
• Relax, It's Just Sex (1998)
• Poison Ivy: The New Seduction (1997)
• Cry-Baby (1990)
• Document of the Dead (1989)
• Big Top Pee-wee (1988)
• The Chipmunk Adventure (1987)
• Avenging Angel (1985)
• Angel (1984)
• Night Warning (1983)
• Forbidden Zone (1980)
• Andy Warhol's Bad (1977)
• I Never Promised You a Rose Garden (1977)
• Wizards (1977) (uncredited)
• Fat City (1972)
• Shoot Out (1971)

• LA Weekly: "My So-Called Rotten Life" by Paul Cullum (11/1/2000)
• Susan Tyrrell at the Internet Movie Database