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TGF alpha
From Wikipedia, the free encyclopedia
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transforming growth factor, alpha
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| Identifiers | |
| Symbol | TGFA |
| HUGO | 11765 |
| Entrez | 7039 |
| OMIM | 190170 |
| RefSeq | NM_003236 |
| UniProt | P01135 |
| Other data | |
| Locus | Chr. 2 p13 |
TGFα is upregulated in some human cancers. It is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development. It is closely related to EGF, and can also bind to the EGF receptor with similar effects . TGFα stimulates neural cell proliferation in the adult injured brain.[1]
TGFα was cited in the 2001 NIH Stem Cell report to the U.S. Congress as promising evidence for the ability of adult stem cells to restore function in neurodegenerative disorders.
- ^ In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain. Proc Natl Acad Sci USA. 2000 Dec 19; 97(26): 14686-91; PubMed Free text
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This biochemistry article is a stub. You can help Wikipedia by expanding it. |
Signaling proteins: Hedgehog - Integrin - JAK/STAT (JAK/STAT) - MAPK/ERK pathway (MAPK/ERK) - NF-kB - Notch - p53 - Wnt (Frzb)
Epidermal growth factor - Fibroblast growth factor (FGF2) - Nerve growth factor - Platelet-derived growth factor - Transforming growth factor (TGFα, TGFβ, TGFβ pathway)