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Thiabendazole
From Wikipedia, the free encyclopedia
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Thiabendazole
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| Systematic (IUPAC) name | |
| 2-(1,3-thiazol-4-yl)-1H-benzoimidazole | |
| Identifiers | |
| CAS number | |
| ATC code | D01 P02CA02 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C10H7N3S |
| Mol. mass | 201.249 g/mol |
| SMILES | search in , |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
Thiabendazole (or tiabendazole) is a fungicide and parasiticide.
Thiabendazole is abbreviated to "TBZ". It is produced by Merck under the brand name Mintezol®.
It is used primarily to control mold, blight, and other fungally caused diseases in fruits and vegetables. It is able to control roundworms, hookworms, and other helminth species which attack wild animals, livestock and humans.
Thiabendazole is applied to some bananas, including Chiquita brand bananas 'to ensure freshness'.
Thiabendazole is also a chelating agent, which means that it is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning.
Thiabendazole is also used as a food additive, a preservative with E number E233.
Thiabendazole is also used to treat ear infections in dogs and cats. It is sold by Merial under the brand name Tresaderm.
The substance appears to have a slight toxicity in higher doses, with effects such as liver and intestine distorder at high exposure in test animals (just below LD50 level). Some reproductive distorders and decreasing weanling weight have been observed, also at high exposure. Effects on humans from use as drug includes nausea, vomiting, loss of appetite, diarrhea, dizziness, drowsiness, or headache; very rarely also ringing in the ears, vision changes, stomach pain, yellowing eyes and skin, dark urine, fever, fatigue, increased thirst and change in the amount of urine. No mutagenic or carcinogenic effects have been shown.
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| Antibiotics | Griseofulvin • polyene antimycotics (Natamycin, Nystatin) |
| Topical azoles | imidazoles (Bifonazole, Clomidazole, Clotrimazole, Econazole, Fenticonazole, Ketoconazole, Isoconazole, Miconazole, Oxiconazole, Sertaconazole, Sulconazole, Tioconazole) • triazoles (Fluconazole) • benzimidazole (Thiabendazole) |
| Other topicals | Ciclopirox • Ethylparaben • Flucytosine • Salicylic acid • Selenium sulfide • Tolnaftate • Undecylenic acid • allylamines (Amorolfine, Butenafine, Naftifine, Terbinafine) |
| For systemic use | Griseofulvin • allylamine (Terbinafine) • polyene antimycotic (Amphotericin B) • triazoles (Itraconazole, Posaconazole, Voriconazole) • echinocandins (Anidulafungin, Caspofungin, Micafungin) |
| Other | Tea tree oil • citronella oil • lemon grass • orange oil • patchouli • lemon myrtle |