Thyroxine-binding globulin

From Wikipedia, the free encyclopedia

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
Identifiers
Symbol SERPINA7 TBG
HUGO 11583
Entrez 6906
OMIM 314200
RefSeq NM_000354
UniProt P05543
Other data
Locus Chr. X q21-q22

Thyroxine-binding globulin (TBG) is one of three proteins (along with transthyretin and albumin) responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3’-triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 in serum. Due to the very low serum concentration of T4 & T3, TBG is rarely more than 25% saturated with its ligand. Unlike transthyretin and albumin, TBG has a single binding site for T4/T3.

TBG is produced in the liver .

Genomically, TBG is a serpin, although it has no inhibitory function like many other members of this class of proteins. TBG is synthesized primarily in the liver as a 54 kDa protein.

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v • d • e
Serpins

Alpha 1-antichymotrypsin - Alpha 1-antitrypsin - Alpha 2-antiplasmin - Antithrombin - C1-inhibitor - Heat shock protein 47 - Heparin cofactor II - Protein C inhibitor - Plasminogen activator inhibitor-1 - Plasminogen activator inhibitor-2 - Protein Z-related protease inhibitor

noninhibitory: Maspin - Ovalbumin - Thyroxine-binding globulin - Transcortin

v • d • e
Proteins: carrier proteins

Acyl carrier protein - Adaptor protein - F-box protein - GTP-binding protein - Light-harvesting complex - Membrane transport protein

Calcium-binding protein - Calmodulin-binding proteins - Ceruloplasmin - Cholesterylester transfer protein - Iron-binding proteins - Retinol binding protein - Transferrin receptor - Transcobalamins

Follistatin - Growth hormone binding protein - Insulin-like growth factor binding protein - Neurophysins (Neurophysin I, II)
Sex hormone binding globulin/Androgen binding protein - Transcortin - Thyroxine-binding globulin - Transthyretin

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