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Torasemide
From Wikipedia, the free encyclopedia
(Redirected from Torsemide)
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Torasemide
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| Systematic (IUPAC) name | |
| 1-[4-(3-methylphenyl) aminopyridin-3-yl] sulfonyl-3-propan-2-yl-urea | |
| Identifiers | |
| CAS number | |
| ATC code | C03 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C16H20N4O3S |
| Mol. mass | 348.421 g/mol |
| SMILES | search in , |
| Pharmacokinetic data | |
| Bioavailability | 80-90% |
| Protein binding | Highly bound (>99%). |
| Metabolism | Hepatic (80%) |
| Half life | 3.5 hours; Cirrhosis: 7-8 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
C(US) |
| Legal status | |
| Routes | Oral, IV |
Torasemide (rINN) or torsemide (USAN) is a pyridine-sulfonylurea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand name Demadex.
Compared to other loop diuretics, torasemide has a more prolonged diuretic effect than equipotent doses of furosemide and relatively decreased potassium-loss. There is no evidence of torasemide-induced ototoxicity demonstrated in humans (Dunn et al., 1995).
- Dunn CJ, Fitton A, Brogden RN. Torasemide. An update of its pharmacological properties and therapeutic efficacy. Drugs. 1995 Jan;49(1):121-42. PMID 7705212
- Medlineplus drug information: Torsemide (Systemic) – information from USP DI Advice for the Patient
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| Antiadrenergic agents (including alpha) | centrally acting (Clonidine, Guanfacine, Methyldopa, Moxonidine, Rescinnamine, Reserpine, Rilmenidine) • ganglion-blocking/nicotinic antagonist (Mecamylamine, Trimethaphan) • peripherally acting (Prazosin, Guanethidine, Indoramin, Doxazosin) |
| Vasodilators | Diazoxide • Hydralazine • Minoxidil • Nitroprusside • Phentolamine |
| Other antihypertensives | serotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan) |
| Low ceiling diuretics | Thiazide (Bendroflumethiazide, Chlorothiazide, Hydrochlorothiazide) • Chlortalidone • Indapamide • Quinethazone • Mersalyl • Metolazone • Theobromine • Cicletanine |
| High ceiling diuretics | Loop diuretic (Bumetanide, Furosemide, Torasemide) |
| Potassium-sparing diuretics | ESC blockers (Amiloride, Triamterene) • aldosterone antagonists (Spironolactone, Eplerenone, Potassium canrenoate, Canrenone) |
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