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Transcortin
From Wikipedia, the free encyclopedia
(Redirected from Cortisol binding globulin)
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| Structure of corticosteroid-binding globulin in complex with cortisol. | |
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Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, also Corticosteroid-Binding Globulin or Transcortin
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| Identifiers | |
| Symbol | SERPINA6 |
| Alt. Symbols | CBG |
| Entrez | 866 |
| HUGO | 1540 |
| OMIM | 122500 |
| RefSeq | NM_001750 |
| UniProt | P08185 |
| Other data | |
| Locus | Chr. 14 q32.1 |
Transcortin, also corticosteroid-binding globulin or CBG, is officially called serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6.
It is an alpha-globulin.
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Transcortin binds several steroid hormones:
- Cortisol. Approximately 75% of the cortisol in circulation is bound to this plasma protein. (The rest is bound to serum albumin.) The cortisol is thought to be biologically active only when it is not bound to transcortin.
- Aldosterone. 60% of the aldosterone in blood is bound to this plasma protein.
Transcortin is produced by the liver and is regulated by estrogens. Therefore, plasma transcortin levels increase during pregnancy, and are decreased in cirrhosis.
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| Hormone | Follistatin - Growth hormone binding protein - Insulin-like growth factor binding protein - Neurophysins (Neurophysin I, II) Sex hormone binding globulin/Androgen binding protein - Transcortin - Thyroxine-binding globulin - Transthyretin |
| Metal/element | calcium (Calcium-binding protein, Calmodulin-binding proteins) - copper (Ceruloplasmin) - iron (Iron-binding proteins, Transferrin receptor) |
| Vitamin | Retinol binding protein (4) - Transcobalamins |
| Other | Acyl carrier protein - Adaptor protein - Cholesterylester transfer protein - F-box protein - GTP-binding protein - Latent TGF-beta binding protein - Light-harvesting complex - Membrane transport protein |
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| inhibitory | Alpha 1-antichymotrypsin - Alpha 1-antitrypsin - Alpha 2-antiplasmin - Antithrombin - C1-inhibitor - Heparin cofactor II - Protein C inhibitor - Plasminogen activator inhibitor-1 - Plasminogen activator inhibitor-2 - Protein Z-related protease inhibitor |
| noninhibitory | Maspin - Ovalbumin - Heat shock protein 47 - Thyroxine-binding globulin - Transcortin |