Tropicamide

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Tropicamide
Systematic (IUPAC) name
N-ethyl-3-hydroxy-2-phenyl-N- (pyridin-4-ylmethyl) propanamide
Identifiers
CAS number 1508-75-4
ATC code S01FA06
PubChem 5593
DrugBank APRD00287
Chemical data
Formula C17H20N2O2 
Mol. mass 284.353 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 45%
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Tropicamide (troe-PIK-a-mide) is a muscarinic acetylcholine receptor blocker. It is used to dilate (enlarge) the pupil of the eye in order to allow better examination of the lens, vitreous humor, and retina. Due to its relatively short duration of effect (4 - 8 hours), it is typically used during eye examinations, but may also be used before or after eye surgery.

Application of tropicamide produces short acting mydriasis (dilation) and cycloplegia. Systemic side effects are very rare, although loss of consciousness has been reported in a ten-year-old child after administration of tropicamide eyedrops.[citation needed]

Tropicamide, a parasympatholytic, is occasionally administered in eye drops in combination with p-hydroxyamphetamine (brand name Paremyd), which is a sympathomimetic. The use of drugs stimulating multiple divisions of the autonomic nervous system ensures the dilation the pupil without opposing muscle group firing.

Other brand names include Mydriacyl.

Right eye was instilled by tropicamide, producing anisocoria (unequal pupil size). It is mydriatic (dilated) compared to the left eye.
Right eye was instilled by tropicamide, producing anisocoria (unequal pupil size). It is mydriatic (dilated) compared to the left eye.
Right eye half an hour after administration of tropicamide. Note the red retina.
Right eye half an hour after administration of tropicamide. Note the red retina.


Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
Ophthalmologicals: mydriatics and cycloplegics (S01F)
Anticholinergics/antimuscarinics Atropine - Scopolamine - Methylscopolamine - Cyclopentolate - Homatropine - Tropicamide
Sympathomimetics Phenylephrine - Ephedrine - Ibopamine
Retrieved from "http://en.wikipedia.org/wiki/Tropicamide"
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