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Tweaking is a slang term of someone in a state of confusion.

Tweaking is most often used by the general public to describe someone exhibiting pronounced symptoms of methamphetamine use, including punding (the repetitive performance of useless tasks), hyperactivity, an inhibited ability to relate socially, lack of appetite, inattention to bodily hygiene, exaggerated fidgeting, or formication (the false sense of things crawling on or under the skin). It is also commonly referred to as "tweeking", a term derived from the user's predilection of staying up for days on end while under the influence, sometimes for as long as "two weeks".

Amongst amphetamine users it sometimes refers only to the negative effects of the drug's use; other times it may be used to describe being under the influence of the drug whether or not this is obvious to others. Users frequently report that the negative effects of methamphetamine use can be abated by remembering to eat, drink and bathe while under the influence, suggesting that the psychosis may sometimes be caused by sleep and food deprivation rather than by the drug directly.

The term may also refer to the effects of other (non-amphetamine) stimulants, such as cocaine, methylphenidate or even caffeine.

• This article contains text taken from the public domain NDIC Narcotics Digest Weekly 2005;4(2):1

• www.Tweaker.org Positioned as a resource helping gay and bisexual men the site includes useful information on speed's effects on one's body and strategies for harm reduction, cutting back and even quitting.
• www.CrystalNeon.org A program of Seattle Counseling Services includes harm reduction, and making changes resources.
• www.Erowid.org Online library of psychoactive plants, chemicals and related topics.
• www.HarmReduction.org A coalition of harm reduction advocates with resources and insightful help for those dealing with drug issues as well as those trying to provide help.
• www.DanceSafe.org A community-driven project from the rave culture gives non-judgmental information considered "youth-friendly" and well-informed. DanceSafe has pioneered many harm-reduction campaigns.