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VLDL receptor
From Wikipedia, the free encyclopedia
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very low density lipoprotein receptor
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| Identifiers | |
| Symbol | VLDLR |
| HUGO | 12698 |
| Entrez | 7436 |
| OMIM | 192977 |
| RefSeq | NM_003383 |
| UniProt | P98155 |
| Other data | |
| Locus | Chr. 9 p24 |
The very-low-density-lipoprotein receptor (VLDLR) is a lipoprotein receptor that shows considerable similarity to the low-density-lipoprotein receptor. This receptor has been suggested to be important for the metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, such as very-low-density-lipoprotein (VLDL), beta-migrating VLDL and intermediate-density lipoprotein.
In rabbits, the mRNA for the VLDLR was found to be most abundant in heart, skeletal muscle, and adipose tissue, but was not detectable in the liver. Human mRNA studies showed a very similar pattern of distribution. Hence, it has been suggested that the VLDLR might play an important role in the fatty acid metabolism of non-hepatic tissues.
- Oka K, Ishimura-Oka K, Chu MJ, Sullivan M, Krushkal J, Li WH, Chan L. (1994) Eur J Biochem. Sep 15;224(3):975-82 Mouse very-low-density-lipoprotein receptor (VLDLR) cDNA cloning, tissue-specific expression and evolutionary relationship with the low-density-lipoprotein receptor. PMID 7925422
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