Related Directory Categories
- Valproate (2)
Sources
Help build the largest human-edited directory on the web.
Submit a site - Become an editor
Wikipedia. Licensed under the GNU Free Documentation License.
Are you an expert in this subject? Join the discussion and share your knowledge at Wikipedia.org.
Sodium valproate
From Wikipedia, the free encyclopedia
 |
|
|
Sodium valproate
|
|
| Systematic (IUPAC) name | |
| sodium 2-propylpentanoate | |
| Identifiers | |
| CAS number | |
| ATC code | N03 |
| PubChem | |
| Chemical data | |
| Formula | C8H15NaO2 |
| Mol. mass | 166.20 |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 90-95% |
| Metabolism | 75% by CYP enzymes |
| Half life | 9 -18 hours |
| Excretion | 20% excreted as glucuronide |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status | |
| Routes | oral, i.v. |
Sodium valproate (INN) or valproate sodium (USAN) is the sodium salt of valproic acid and is an anticonvulsant used in the treatment of epilepsy; as well as being used as a mood stabilizer. The intravenous formulations are used when oral administration is not possible.
Contents |
- Intravenous injection – Depacon® by Abbott Laboratories.
- Syrup – Depakene by Abbott Laboratories. (Note Depakene capsules are valproic acid).
- Tablets – Orlept® by Wockhardt and Epilim® by Sanofi-Aventis.
- Oral solution – Orlept® Sugar Free by Wockhardt and Epilim® by Sanofi-Aventis.
- Syrup – Epilim® by Sanofi-Aventis.
- Intravenous injection – Epilim® Intravenous by Sanofi-Aventis.
- Extended release tablets – Epilim Chrono® by Sanofi-Aventis. A combination of sodium valproate and valproic acid in a 2.3:1 ratio.
- Enteric-coated tablets – Epilim® EC200 by Sanofi-synthelabo. A 200mg Sodium Valporate enteric-coated tablet.
- Tablets – Orfiril® by Desitin Pharmaceuticals
- Intravenous injection – Orfiril® IV by Desitin Pharmaceuticals
- Syrup – Convulex® by Byk Madaus
- Intravenous injection – Epival® or Epiject® by Abbott Laboratories.
- Syrup – Depakene® by Abbott Laboratories. Generic formulations include Apo-Valproic and ratio-Valproic.
In much of Europe, Depakine® and Depakine Chrono® are equivalent to Epilim and Epilim Chrono above.
- Chemical Land21: Sodium Valproate
- RXList.com: Depacon (Sodium Valproate)
- British National Formulary Edition 50
- Med Broadcast.com: Epival
- Drugs.com: Depaken Syrup
Barbiturates: Barbexaclone, Metharbital, Methylphenobarbital, Phenobarbital, Primidone
Hydantoins: Ethotoin, Fosphenytoin, Mephenytoin, Phenytoin
Oxazolidinediones: Ethadione, Paramethadione, Trimethadione
Succinimides: Ethosuximide, Mesuximide, Phensuximide
Benzodiazepines: Clobazam, Clonazepam, Clorazepate, Diazepam, Lorazepam, Midazolam, Nitrazepam, Temazepam
Carboxamides: Carbamazepine, Oxcarbazepine, Rufinamide Fatty acid derivatives: Valpromide, Valnoctamide
Carboxylic acids: Valproic acid (Sodium valproate & Valproate semisodium), Tiagabine -- GABA analogs: Gabapentin, Pregabalin, Progabide, Vigabatrin
Others:- Monosaccharides: Topiramate -- Aromatic allylic alcohols: Stiripentol -- Ureas: Phenacemide, Pheneturide -- Phenyltriazines: Lamotrigine
Carbamates: Emylcamate, Felbamate, Meprobamate -- Pyrrolidines: Brivaracetam, Levetiracetam, Nefiracetam, Seletracetam
Sulfa drugs: Acetazolamide, Ethoxzolamide, Sultiame, Zonisamide -- Propionates: Beclamide -- Aldehydes: Paraldehyde -- Bromides: Potassium bromide, Sodium bromide