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Verapamil
Systematic (IUPAC) name
2-(3,4-dimethoxyphenyl)-5-[2-(3,4- dimethoxyphenyl)ethyl-methyl-amino] -2-(1-methylethyl)pentanenitrile
Identifiers
CAS number	52-53-9
ATC code	C08DA01
PubChem	2520
DrugBank	APRD00335
Chemical data
Formula	C27H38N2O4
Mol. mass	454.602 g/mol
Pharmacokinetic data
Bioavailability	35.1%
Metabolism	Hepatic
Half life	2.8-7.4 hours
Excretion	Renal: 11%
Therapeutic considerations
Pregnancy cat.	C(US)
Legal status	℞ Prescription only
Routes	Oral, Intravenous

Verapamil (brand names: Isoptin, Verelan, Calan, Bosoptin) is an L-type calcium channel blocker. It has been used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and most recently, headaches.^[1] Verapamil has also been used as a vasodilator during cryopreservation of blood vessels. It is a class 4 antiarrhythmic, more effective than digoxin in controlling ventricular rate, and was approved by the FDA in 1981. Interestingly, one of its purified isomers may not cause constipation (a well-known adverse effect of racemic verapamil).

Verapamil's mechanism in all cases is to block voltage-dependent Calcium channels.

In cardiac pharmacology, Calcium channel blockers are considered class IV antiarrhythmic agents. Since Calcium channels are especially concentrated in the sinoatrial and atrio-ventricular nodes, these agents can be used to decrease impulse conduction through the AV node, thus protecting the ventricles from atrial tachyarrhythmias.

Calcium channels are also present in the smooth muscle that lines blood vessels. By relaxing the tone of this smooth muscle, calcium-channel blockers dilate the blood vessels. This has led to their use in treating hypertension and angina pectoris.

The pain of angina is caused by a deficit in oxygen supply to the heart. Calcium channel blockers like Verapamil will dilate blood vessels, which increases the supply of blood and oxygen to the heart. This controls chest pain, but only when used regularly. It does not stop chest pain once it starts. A more powerful vasodilator such as nitroglycerin may be needed to control pain once it starts.

Given orally, 90–100% of Verapamil is absorbed, but due to high first-pass metabolism, bioavailability is much lower (10–35%). It is 90% bound to plasma proteins and has a volume of distribution of 3–5 L/kg^-1. It is metabolized in the liver to at least 12 inactive metabolites (though one metabolite, norverapamil, retains 20% of the vasodilating activity of the parent drug). As its metabolites, 70% is excreted in the urine and 16% in feces; 3–4% is excreted unchanged in urine. This is a non-linear dependence between plasma concentration and dosage. Onset of action is 1-2 hours after oral dosage. Half-life is 5-12 hours (with chronic dosages). It is not cleared by hemodialysis.

Verapamil has an anti-manic effect but is rarely used for mania. It has on occasion been used used to control mania in pregnant patients, especially in the first 3 months. It does not appear to be significantly teratogenic. For this reason, when one wants to avoid taking valproic acid (which is high in teratogenicity) or lithium (which has a small but significant incidence of causing cardiac malformation), Verapamil is usable as an alternative, albeit presumably a less effective one.

Some possible side effects of the drug are headaches, facial flushing, dizziness, swelling, increased urination, and constipation.

Verapamil is also used in cell biology as an inhibitor of drug efflux pump proteins such as P-glycoprotein.^[2] This is useful as many tumor cell lines overexpress drug efflux pumps, limiting the effectiveness of cytotoxic drugs or fluorescent tags. It's also used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorochromes such as Hoechst 33342.

1. ^ Management of Cluster Headaches, (Beck et al. 2005) American Family Physician Vol 71, No.4 Full Free Text: http://www.aafp.org/afp/20050215/717.html
2. ^ Bellamy WT. P-glycoproteins and multidrug resistance. Annu Rev Pharmacol Toxicol 1996; 36:161-83. PMID 8725386

• MedlinePlus DrugInfo medmaster-a684030
• Securon Summary of Product Characteristics