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XPB
From Wikipedia, the free encyclopedia
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excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)
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| Identifiers | |
| Symbol | ERCC3 |
| HUGO | 3435 |
| Entrez | 2071 |
| OMIM | 133510 |
| RefSeq | NM_000122 |
| UniProt | P19447 |
| Other data | |
| Locus | Chr. 2 q21 |
XPB (Xeroderma Pigmentosum B) is an ATP dependent human DNA helicase that is a part of the TFIIH transcription factor complex.
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The 3D structure of the archeael homologue of XPB has been solved by X-ray crystallography by Dr. John Tainer and his group at The Scripps Research Institute.[1]
XPG plays a significant role in normal basal transcription, transcription coupled repair (TCR), and nucleotide excision repair (NER). Purified XPB has been shown to unwind DNA with 3’-5’polarity.
Mutations in XPB and other related complementation groups, XPA-XPG, leads to a number of genetic disorders such as Xeroderma Pigmentosum, Cockayne's syndrome, and Trichothiodystrophy.
- ^ Fan L, Arvai A, Cooper P, Iwai S, Hanaoka F, Tainer J (2006). "Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair". Mol Cell 22 (1): 27-37. PMID 16600867.
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